Ĭandida albicans is an opportunistic microorganism that dramatically infects people with AIDS and with bone marrow transplantation. The stimulation of the detoxification enzyme seems to be another mechanism responsible for its anticarcinogenic action. This may be associated with its ability to eliminate reactive oxygen species (ROS) and stimulate cytoprotective enzymes, causing a decrease in lipid peroxidation, rupture of the double strand of DNA, inactivation of certain proteins, and disruption of biological membranes. Recent studies have demonstrated ferulic acid as a potential agent against some tumors.
The presence of these characteristics has been depicted from numerous studies reported in the literature that show the pharmacological activity of ferulic acid in experimental models related to several pathologies, including diabetes, neurodegenerative diseases, and cardiovascular disease.
#REAL ACTION POSE COLLECTION VOL 3 FREE#
It is well known potent phenolic antioxidant that has the property of scavenging free radicals and induce antioxidant enzymes, such as catalase and superoxide dismutase (SOD), in order to protect cellular macromolecules of peroxidation and oxidative damage. Introductionįerulic acid (4-hydroxy-3-methoxycinnamic acid) is a natural organic compound abundantly distributed in fruits and vegetables. The findings of the present study demonstrated that compounds 10 and 11 may be used as a platform in drug development in the future. Molecular modeling suggested that compounds 10 and 11 interact with the enzymes GWT1 and GSC1, which are essential for the development of C. The possible mechanism of antifungal action occurs via the fungal cell wall. This amide had antifungal activity in all strains and had the lowest MIC against Candida albicans and Candida tropicalis. The amides 10 and 11 displayed the best result in both biological evaluations, and compound 10 was the most potent and selective in HL-60 cancer cells, with no cytotoxicity on healthy cells. The compounds were subjected to cytotoxic tests by the alamar blue technique and antifungal screening by the broth microdilution method to determine the minimum inhibitory concentration (MIC). All the compounds were identified on the basis of their IR, 1H- and 13C-NMR, HRMS data, and with yields ranging from 43.17% to 91.37%.
#REAL ACTION POSE COLLECTION VOL 3 SERIES#
In the present study, a series of ten amides were obtained by coupling reactions using the reagents (benzotriazol-1-yloxy) tripyrrolidinophosphonium hexafluorophosphate (PyBOP) and N,N -dicyclohexylcarbodiimide (DCC). Amides derived from ferulic acid have a wide spectrum of pharmacological activities, including antitumor and antifungal activity.